Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model. Neurosci Lett 2007 May 11;418(1):22-7
Date
03/31/2007Pubmed ID
17395373Pubmed Central ID
PMC2689383DOI
10.1016/j.neulet.2007.02.078Scopus ID
2-s2.0-34247126015 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Activation of the cAMP pathway is an important mediator of chronic muscle pain. This study examined phosphorylation of the transcription factor cAMP-response-element-binding protein (p-CREB) and the NR1 subunit of the NMDA receptor (p-NR1) in the spinal cord. Bilateral mechanical hyperalgesia of the paw was induced by administering two injections of acidic saline, 5 days apart, into the gastrocnemius muscle of male Sprague-Dawley rats. The proportion of spinothalamic neurons that expressed p-NR1 or p-CREB did not change in the dorsal horn 24h after the second intramuscular acid injection compared with animals that received pH 7.2 injections. This lack of change in spinothalamic neurons in the dorsal horn may be due to increases in individual spinothalamic neurons or increases in non-spinothalamic neurons. There was an increase in the proportion of spinothalamic neurons expressing p-NR1 in lamina X. These findings suggest that there are region-specific changes in spinothalamic neurons that express p-NR1 and lamina X may play an important role in the modulation of chronic muscle pain.
Author List
Bement MK, Sluka KAAuthor
Marie Hoeger Bement MPT,PhD Associate Professor in the Physical Therapy department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnimalsChronic Disease
Cyclic AMP Response Element-Binding Protein
Disease Models, Animal
Hyperalgesia
Male
Muscle, Skeletal
Neurons
Pain
Phosphorylation
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate
Spinothalamic Tracts
