Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner. Arch Phys Med Rehabil 2005 Sep;86(9):1736-40
Date
09/27/2005Pubmed ID
16181935DOI
10.1016/j.apmr.2005.03.029Scopus ID
2-s2.0-25144509437 (requires institutional sign-in at Scopus site) 97 CitationsAbstract
OBJECTIVE: To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system.
DESIGN: Randomized placebo-controlled trial.
SETTING: Animal laboratory.
ANIMALS: Sixty-three male Sprague-Dawley rats.
INTERVENTIONS: Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions.
MAIN OUTCOME MEASURE: Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold.
RESULTS: Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise.
CONCLUSIONS: Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.
Author List
Bement MK, Sluka KAAuthor
Marie Hoeger Bement MPT,PhD Associate Professor in the Physical Therapy department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
Analysis of VarianceAnimals
Area Under Curve
Disease Models, Animal
Male
Muscular Diseases
Naloxone
Pain
Pain Measurement
Physical Conditioning, Animal
Probability
Random Allocation
Rats
Rats, Sprague-Dawley
Sensitivity and Specificity
