Models of muscle pain: carrageenan model and acidic saline model. Curr Protoc Pharmacol 2004 Sep 01;Chapter 5:Unit 5.35
Date
09/01/2004Pubmed ID
22294122DOI
10.1002/0471141755.ph0535s25Scopus ID
2-s2.0-84858846445 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Carrageenan or acidic saline injected unilaterally into the gastrocnemius muscle or triceps muscle produces a robust and long-lasting hyperalgesia in rats and mice, which is reversible with systemic administration of opioid or anti-inflammatory drugs. This unit describes detailed protocols for inducing and measuring hyperalgesia, and provides information on validation of these models. These models are useful for assessing new compounds for their analgesic activity in muscular pain.
Author List
Radhakrishnan R, Bement MK, Skyba D, Sluka KA, Kehl LJAuthor
Marie Hoeger Bement MPT,PhD Associate Professor in the Physical Therapy department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnalgesicsAnimal Husbandry
Animals
Carrageenan
Data Collection
Disease Models, Animal
Drug Evaluation, Preclinical
Hot Temperature
Hyperalgesia
Injections, Subcutaneous
Male
Mice
Muscle Strength
Muscle, Skeletal
Musculoskeletal Pain
Rats
Rats, Sprague-Dawley
Reaction Time
Sodium Chloride
Touch
