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Keratin 7 and ERBB2 Negative Mammary Paget Disease Without an Underlying in Situ and Invasive Carcinoma. Int J Surg Pathol 2022 Aug;30(5):590-592

Date

02/01/2022

Pubmed ID

35098762

DOI

10.1177/10668969221076550

Scopus ID

2-s2.0-85124208414 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

We report a unique case of a post-menopausal female who presented with a lesion on the areola. A biopsy of the lesion demonstrated a pagetoid intraepithelial neoplasm suggesting a differential diagnosis of mammary Paget disease and pagetoid Bowen disease. Excision of the lesion confirmed the diagnosis of mammary Paget disease with typical histological appearance. This case is extremely rare since both keratin 7 and ERBB2 were negative, and there was no evidence of underlying in situ or invasive carcinoma.

Author List

Ratiani M, Farooq A, Jorns J, Sheinin Y

Authors

Julie M. Jorns MD Professor in the Pathology department at Medical College of Wisconsin
Yuri M. Sheinin MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
Carcinoma in Situ
Female
Humans
Keratin-7
Nipples
Paget's Disease, Mammary
Receptor, ErbB-2