Medical College of Wisconsin
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Conjugated hyperbilirubinemia in children. Pediatr Rev 2012 Jul;33(7):291-302

Date

07/04/2012

Pubmed ID

22753787

DOI

10.1542/pir.33-7-291

Scopus ID

2-s2.0-84863546718 (requires institutional sign-in at Scopus site)   39 Citations

Abstract

A variety of anatomic, infectious, autoimmune, and metabolic diseases can lead to conjugated hyperbilirubinemia, both in the newborn period and later in childhood. The pediatric practitioner is most likely to encounter conjugated hyperbilirubinemia in the neonatal period.It is crucial to maintain a high degree of suspicion for cholestasis in the persistently jaundiced newborn. The goal is recognition of conjugated hyperbilirubinemia between 2 and 4 weeks after birth, allowing for the prompt identification and management of infants who have biliary atresia, which remains the most common cause of neonatal cholestasis.

Author List

Brumbaugh D, Mack C

Author

Cara Lynn Mack MD Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Alagille Syndrome
Alanine Transaminase
Aspartate Aminotransferases
Autoimmune Diseases
Biliary Atresia
Biliary Tract Diseases
Bilirubin
Child
Choledochal Cyst
Cholestasis, Extrahepatic
Diagnosis, Differential
Gallstones
Hepatitis A
Hepatolenticular Degeneration
Humans
Hyperbilirubinemia
Infant
Infant, Newborn
Liver Diseases
Neonatal Screening