Faculty Collaboration Database

Whole body hyperthermia cytokine induction: a review, and unifying hypothesis for myeloprotection in the setting of cytotoxic therapy. Cytokine Growth Factor Rev 1999 Jun;10(2):93-7

Date

04/01/2000

Pubmed ID

10743501

DOI

10.1016/s1359-6101(99)00006-4

Scopus ID

2-s2.0-0032832940 (requires institutional sign-in at Scopus site)   56 Citations

Abstract

Whole Body Hyperthermia (WBH) enhancement of chemotherapy and/or radiation without a concomitant increase in myelosuppression has been documented in clinical trials. We propose that the biological basis for this phenomena relates in part to the previously reported induction of peripheral cytokines by WBH, that is, granulocyte colony stimulating factor (G-CSF), interleukin (IL)-1 beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha), and the regulatory cytokine IL-10. To further explain this myeloprotection and the additional clinical observation that WBH promotes early engraftment of bone marrow (when used as part of an allogenic bone marrow transplant preconditioning regimen) we developed a hypothesis: WBH increases peripheral IL-1 beta, IL-6, and TNF-alpha resulting in a secondary induction of IL-3 and granulocyte macrophage colony stimulating factor (GM-CSF) in the bone marrow, for which supportive data also exists. Taken collectively, these data provide an increased understanding of the biological sequelae of fever, as well as a testable unifying hypothesis, for future antineoplastic treatment strategies.

Author List

Katschinski DM, Wiedemann GJ, Longo W, d'Oleire FR, Spriggs D, Robins HI

Author

Walter L. Longo MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Bone Marrow
Cytokines
Fever
Granulocyte Colony-Stimulating Factor
Humans
Hypothermia, Induced
Models, Biological
Neoplasms
Tumor Necrosis Factor-alpha