Daily Physical Activity and Symptom Reporting in Breast Cancer Patients Undergoing Chemotherapy: An Intensive Longitudinal Examination. Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2608-2616
Date
10/01/2020Pubmed ID
32994340Pubmed Central ID
PMC7710582DOI
10.1158/1055-9965.EPI-20-0659Scopus ID
2-s2.0-85100991034 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
BACKGROUND: Increased activity is beneficial during chemotherapy, but treatment-related symptoms may be a barrier. This study examines the relationship between daily fluctuations in symptoms and activity during chemotherapy.
METHODS: Women undergoing chemotherapy for breast cancer [n = 67; M age = 48.6 (SD = 10.3)] wore an accelerometer 24 hours/day and received four text prompts/day to rate symptoms for 10 consecutive days at the beginning, middle, and end of chemotherapy. Mixed-effects models were used to examine the between and within-person relationships between symptom ratings on a given day and moderate to vigorous physical activity (MVPA) and light physical activity (LPA) on that day and the following day controlling for relevant covariates and using the Bonferroni correction for multiple comparisons.
RESULTS: For MVPA and LPA, within-person associations were statistically significant for same day affect, fatigue, pain, walking, activities of daily living (ADL) physical function, and cognitive function. Previous day anxiety was associated with next day LPA. Every one point worse symptom rating than an individual's overall average was associated with: (i) between 1.49 (pain) and 4.94 (fatigue) minutes less MVPA and between 4.48 (pain) and 24.72 (ADL physical function) minutes less LPA that day, and (ii) 11.28 minutes less LPA the next day. No between-person effects were significant for MVPA or LPA.
CONCLUSIONS: Daily within-person variations in symptoms were associated with MVPA and LPA during chemotherapy for breast cancer.
IMPACT: Future work should explore relationships between symptoms and activity further and identify whether tailoring to symptoms enhances efficacy of physical activity promotion interventions during chemotherapy.
Author List
Phillips SM, Welch WA, Fanning J, Santa-Maria CA, Gavin KL, Auster-Gussman LA, Solk P, Lu M, Cullather E, Khan SA, Kulkarni SA, Gradishar W, Siddique JAuthors
Kara L. Gavin Research Scientist II in the Center for Advancing Population Science department at Medical College of WisconsinWhitney A. Morelli PhD Assistant Professor in the Physical Medicine and Rehabilitation department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AccelerometryBreast Neoplasms
Exercise
Female
Humans
Longitudinal Studies
Middle Aged
Prospective Studies
