Faculty Collaboration Database

Antenatal maternal hypoglycemia in women with gestational diabetes mellitus and neonatal outcomes. J Perinatol 2022 Aug;42(8):1091-1096

Date

02/24/2022

Pubmed ID

35194160

DOI

10.1038/s41372-022-01350-4

Scopus ID

2-s2.0-85124956669 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

OBJECTIVE: To examine the prevalence of antenatal maternal hypoglycemia after initiation of pharmacotherapy for gestational diabetes mellitus (GDMA2) and its association with pregnancy outcomes.

STUDY DESIGN: Retrospective cohort of GDMA2 women receiving either insulin or oral hypoglycemic agents. Composite neonatal outcome included macrosomia, jaundice, respiratory distress syndrome, large for gestational age, shoulder dystocia, birth trauma, 5-minute Apgar < 7, and neonatal hypoglycemia, and was compared between women with and without hypoglycemia using bivariate and multivariate analyses.

RESULTS: Of 489 women included in the study, 95 (19.4%) had at least one episode of hypoglycemia, most often in the setting of glyburide. Newborns exposed to maternal hypoglycemia had higher rates of the composite neonatal outcome (54.7% vs. 38.3%, p = 0.004). After controlling for confounding factors, maternal hypoglycemia remained independently associated with the composite neonatal outcome (aOR = 1.69, 95% CI 1.04-2.72).

CONCLUSION: Maternal hypoglycemia in GDMA2 was associated with higher rates of adverse neonatal outcomes.

Author List

Harrison RK, Saravanan V, Davitt C, Cruz M, Palatnik A

Authors

Meredith Cruz MD Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
Anna Palatnik MD Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Diabetes, Gestational
Female
Fetal Macrosomia
Glyburide
Humans
Hypoglycemia
Hypoglycemic Agents
Infant, Newborn
Infant, Newborn, Diseases
Pregnancy
Pregnancy Outcome
Retrospective Studies
Weight Gain