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Physician assessment of changing lesion size of predominantly classic choroidal neovascular membranes in age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2009;40(6):554-60

Date

11/26/2009

Pubmed ID

19928720

DOI

10.3928/15428877-20091030-04

Scopus ID

2-s2.0-72249116170 (requires institutional sign-in at Scopus site)

Abstract

BACKGROUND AND OBJECTIVE: To quantify the interpretation of fluorescein angiograms of evolving predominantly classic choroidal neovascularization in age-related macular degeneration.

PATIENTS AND METHODS: Thirty-six fluorescein angiograms of predominantly classic choroidal neovascularization were used to define 22 fluorescein angiogram pairs. Imaging software was used to measure surface area and greatest linear dimension (GLD). Six retina physicians estimated the change in surface area and GLD for each pair before and after demarcation of the lesions' borders and GLD.

RESULTS: For enlarging lesions, the smallest changes consistently detected by physicians were a 5% to 15% increase in surface area and a 5% to 15% increase in GLD; for shrinking lesions, they were a 5% to 15% decrease in surface area and a 5% to 15% decrease in GLD. Linear regression demonstrated moderate correlation between physician and software estimates of surface area and GLD change (r(2) = 0.50 and 0.67, respectively; P < .001), which was higher with lesion demarcation (r(2) = 0.91 and 0.93, respectively; P < .001).

CONCLUSION: Computer-assisted demarcation of lesion surface area and GLD reduced variability in physicians' estimates of choroidal neovascularization size change and improved correlation with software measurements.

Author List

Covert DJ, Han DP, Kim JE, Connor TB Jr, Wirostko WJ, Moon SJ, Hamilton R

Authors

Thomas B. Connor MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
William Wirostko MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Choroidal Neovascularization
Clinical Competence
Fluorescein Angiography
Fundus Oculi
Humans
Image Processing, Computer-Assisted
Macular Degeneration
Prospective Studies
Reproducibility of Results