Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Undiagnosed and Rare Diseases in Critical Care: Severe Mucocutaneous Medication Reactions. Crit Care Clin 2022 Apr;38(2):243-269

Date

04/05/2022

Pubmed ID

35369946

DOI

10.1016/j.ccc.2021.11.003

Scopus ID

2-s2.0-85127353227

Abstract

There have been major advances in the understanding of severe cutaneous adverse reactions (SCARs). Early recognition and withdrawal of culprit medications can decrease morbidity and mortality significantly. SCARs encompass a variety of entities that present with extensive mucocutaneous involvement and systemic symptoms, often requiring management in an intensive care setting. Physicians need to recognize SCARs early in their course, including drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis, and their mimicking conditions. This review focuses on common and rare SCARs with an emphasis on defining features, clinical and diagnostic evaluation, treatment, and long-term sequelae.

Author List

Shields BE, Wanat KA, Chiu YE

Authors

Yvonne E. Chiu MD Vice Chair, Professor in the Dermatology department at Medical College of Wisconsin
Karolyn A. Wanat MD Vice Chair, Associate Professor in the Dermatology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Critical Care
Humans
Rare Diseases
Stevens-Johnson Syndrome