Undiagnosed and Rare Diseases in Critical Care: Severe Mucocutaneous Medication Reactions. Crit Care Clin 2022 Apr;38(2):243-269
Date
04/05/2022Pubmed ID
35369946DOI
10.1016/j.ccc.2021.11.003Scopus ID
2-s2.0-85127353227Abstract
There have been major advances in the understanding of severe cutaneous adverse reactions (SCARs). Early recognition and withdrawal of culprit medications can decrease morbidity and mortality significantly. SCARs encompass a variety of entities that present with extensive mucocutaneous involvement and systemic symptoms, often requiring management in an intensive care setting. Physicians need to recognize SCARs early in their course, including drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis, and their mimicking conditions. This review focuses on common and rare SCARs with an emphasis on defining features, clinical and diagnostic evaluation, treatment, and long-term sequelae.
Author List
Shields BE, Wanat KA, Chiu YEAuthors
Yvonne E. Chiu MD Vice Chair, Professor in the Dermatology department at Medical College of WisconsinKarolyn A. Wanat MD Vice Chair, Associate Professor in the Dermatology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Critical CareHumans
Rare Diseases
Stevens-Johnson Syndrome
