CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate. J Exp Med 2022 Jun 06;219(6)
Date
04/20/2022Pubmed ID
35438721Pubmed Central ID
PMC9022290DOI
10.1084/jem.20211314Scopus ID
2-s2.0-85128794972 (requires institutional sign-in at Scopus site) 323 CitationsAbstract
CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and non-immune cells. It functions as both a signaling receptor responding to DAMPs and PAMPs, as well as a long chain free fatty acid transporter. Recent studies have indicated that CD36 can integrate cell signaling and metabolic pathways through its dual functions and thereby influence immune cell differentiation and activation, and ultimately help determine cell fate. Its expression along with its dual functions in both innate and adaptive immune cells contribute to pathogenesis of common diseases, including atherosclerosis and tumor progression, which makes CD36 and its downstream effectors potential therapeutic targets. This review comprehensively examines the dual functions of CD36 in a variety of immune cells, especially macrophages and T cells. We also briefly discuss CD36 function in non-immune cells, such as adipocytes and platelets, which impact the immune system via intercellular communication. Finally, outstanding questions in this field are provided for potential directions of future studies.
Author List
Chen Y, Zhang J, Cui W, Silverstein RLAuthors
Yiliang Chen PhD Assistant Professor in the Medicine department at Medical College of WisconsinRoy L. Silverstein MD Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AtherosclerosisCD36 Antigens
Fatty Acids
Humans
Macrophages
Membrane Transport Proteins
Signal Transduction
