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Radiation as a risk factor for cardiovascular disease. Antioxid Redox Signal 2011 Oct 01;15(7):1945-56



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Pubmed Central ID




Scopus ID

2-s2.0-80052015096   69 Citations


Abstract population are ubiquitous background radiation and medical exposure of patients. From the early 1980s to 2006, the average dose per individual in the United States for all sources of radiation increased by a factor of 1.7-6.2 mSv, with this increase due to the growth of medical imaging procedures. Radiation can place individuals at an increased risk of developing cardiovascular disease. Excess risk of cardiovascular disease occurs a long time after exposure to lower doses of radiation as demonstrated in Japanese atomic bomb survivors. This review examines sources of radiation (atomic bombs, radiation accidents, radiological terrorism, cancer treatment, space exploration, radiosurgery for cardiac arrhythmia, and computed tomography) and the risk for developing cardiovascular disease. The evidence presented suggests an association between cardiovascular disease and exposure to low-to-moderate levels of radiation, as well as the well-known association at high doses. Studies are needed to define the extent that diagnostic and therapeutic radiation results in increased risk factors for cardiovascular disease, to understand the mechanisms involved, and to develop strategies to mitigate or treat radiation-induced cardiovascular disease.

Author List

Baker JE, Moulder JE, Hopewell JW


John E. Baker PhD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cardiovascular Diseases
Chernobyl Nuclear Accident
Environmental Exposure
Lipid Metabolism
Radiation Injuries
Radiation Injuries, Experimental
Radiation Tolerance
Risk Factors
Space Flight
Whole-Body Irradiation
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a