[Ultrastructural changes in the plasma membrane of A-431 cells exposed to epidermal growth factor]. Tsitologiia 1988 Jan;30(1):34-8
Date
01/01/1988Pubmed ID
3258683Scopus ID
2-s2.0-0023672989 (requires institutional sign-in at Scopus site)Abstract
The plasma membrane ultrastructural changes after the action of epidermal growth factor were studied in A-431 cells using freeze-fracture methods. The incubation with EGF (100 ng/ml, 0 degree C, 60 min) led to a decrease in density of intramembrane particles on the P surface of ventral cell membrane, while the number of coated pits increased there. The revealed effects of EGF may be related to direct consequences of EGF-receptor complex formation, because all the temperature dependent steps of its processing were blocked. The data obtained testify to an active involvement of the membrane ventral surface in the formation of cell response towards growth factors.
Author List
Romanov VI, Sorokin AB, Nesterov AM, Komissarchik IaIuAuthor
Andrey Sorokin PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Carcinoma, Squamous CellCell Line
Cell Membrane
Dose-Response Relationship, Drug
Epidermal Growth Factor
Freeze Fracturing
Humans
Microscopy, Electron
Surface Properties
Tumor Cells, Cultured
