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Vasopressin, ACTH, and blood pressure during hypoxia induced at different rates. Am J Physiol 1983 Nov;245(5 Pt 1):E489-93

Date

11/01/1983

Pubmed ID

6314822

DOI

10.1152/ajpendo.1983.245.5.E489

Scopus ID

2-s2.0-0020858162   25 Citations

Abstract

We decreased arterial PO2 at three different rates and measured blood pressure (BP), vasopressin (AVP), ACTH, and corticosteroid levels in nonsurgically stressed, anesthetized, paralyzed dogs. PaO2 was lowered to 28 Torr in 2 (fast), 10 (moderate), and 20 min (slow). The fast dPO2/dt produced a large spike in BP. Increases in AVP, ACTH, and corticosteroids were similar regardless of the dPO2/dt. When the spike in BP during the fast dPO2/dt was prevented with nitroprusside, hormone levels increased more quickly and were higher during the first 20-30 min of hypoxia. By 60 min, hormone levels were not different between experiments. The data suggest that 1) faster decreases in PO2 produce larger increases in BP, 2) increases in AVP, ACTH, and corticosteroids are primarily sensitive to the level of steady-state PaO2, and 3) increases in BP inhibit stress-induced increases in AVP and ACTH.

Author List

Raff H, Shinsako J, Keil LC, Dallman MF

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Hormones
Adrenocorticotropic Hormone
Animals
Arginine Vasopressin
Blood Pressure
Dogs
Fasting
Female
Hypoxia
Kinetics
Male
Nitroprusside
Oxygen
Partial Pressure
Time Factors
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d