Faculty Collaboration Database

Sexual adventurism, high-risk behavior, and human immunodeficiency virus-1 seroconversion among the Chicago MACS-CCS cohort, 1984 to 1992. A case-control study. Sex Transm Dis 1996;23(6):453-60

Date

11/01/1996

Pubmed ID

8946628

DOI

10.1097/00007435-199611000-00003

Scopus ID

2-s2.0-0029844057 (requires institutional sign-in at Scopus site)   46 Citations

Abstract

BACKGROUND AND OBJECTIVES: To predict incident human immunodeficiency virus (HIV)-1 seroconversions among a cohort of gay and bisexual men based on recalled sexual behavior, drug use, partnership status, and an index of sexual adventurism/risk-seeking attitudes.

STUDY DESIGN: A nested case-control design was used in a retrospective study spanning a 9-year period.

RESULTS: Sexual adventurism was an important predictor of HIV-1 infection. The partial risk ratio for our 100-point adventurism scale indicated a marginal rate of increase in seroconversion risk of 4% (odds ratio = 1.04; 95% confidence interval = 1.02 to 1.06), with almost 79% of seroconverters scoring above the median on the index. As expected, partner status, drug use, and unprotected receptive anal (RA) intercourse were associated with seroconversion. However, multivariate results indicated that men using condoms consistently in RA sex were also at higher risk for infection (odds ratio = 2.68; 95% confidence interval = 1.04 to 6.95) than men who abstained from RA intercourse.

CONCLUSIONS: Results are discussed with respect to their implications for HIV prevention intervention and research. Recommendations include the development of new approaches and the adaptation of existing intervention techniques that recognize and treat persons with strong risk-taking predispositions.

Author List

Difranceisco W, Ostrow DG, Chmiel JS

Author

Wayne J. DiFranceisco Research Scientist II in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Analysis of Variance
Case-Control Studies
Chicago
Condoms
HIV Infections
HIV Seropositivity
HIV-1
Homosexuality, Male
Humans
Incidence
Likelihood Functions
Male
Matched-Pair Analysis
Multivariate Analysis
Odds Ratio
Retrospective Studies
Risk Factors
Risk-Taking
Sexual Behavior
Sexual Partners
Substance-Related Disorders