Specific supersensitivity of the mesenteric vascular bed of Dahl salt-sensitive rats. Hypertension 1991 Mar;17(3):349-56
Date
03/01/1991Pubmed ID
1847901DOI
10.1161/01.hyp.17.3.349Scopus ID
2-s2.0-0026034297 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Dahl salt-sensitive (DS) and salt-resistant (DR) rats were maintained on a diet containing normal (0.45%) or high (7%) salt for 5 days. The DS rats had slightly higher systolic blood pressures than DR rats, although a high salt diet failed to significantly elevate pressure in either group when compared with their appropriate (low salt diet) controls. The sensitivity of the isolated, perfused mesenteric vasculature from DS rats fed a high salt diet to nerve stimulation was greater when compared with all other groups in the presence or absence of cocaine (1 microM). A similar difference in sensitivity between high salt DS rats and high salt DR rats to bolus injections of norepinephrine was observed only in the presence of cocaine. The change in sensitivity was characterized by a leftward shift of the dose-response curve without a change in maximum response. No difference in sensitivity between the high salt DS group and any other treatment group was observed in response to the pressor agents KCl, angiotensin II, 5-hydroxytryptamine or the depressor agent acetylcholine. These data indicate that DS rats on a short-term, high salt diet possess a significant and specific elevation in sensitivity to nerve stimulation and norepinephrine in the absence of an increase in blood pressure. Differences in the effectiveness of cocaine among the groups suggest that differences may exist in neuronal uptake (uptake 1).(ABSTRACT TRUNCATED AT 250 WORDS)
Author List
Kong JQ, Taylor DA, Fleming WW, Kotchen TAMESH terms used to index this publication - Major topics in bold
AcetylcholineAnimals
Blood Pressure
Cocaine
Dose-Response Relationship, Drug
Electric Stimulation
Hypertension
In Vitro Techniques
Male
Mesentery
Muscle, Smooth, Vascular
Norepinephrine
Potassium Chloride
Rats
Receptors, Adrenergic, alpha
Sodium Chloride