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Investigations of Bis(alkylthiocarbamato)copper Linkage Isomers. Inorg Chem 2022 May 23;61(20):7715-7719

Date

05/14/2022

Pubmed ID

35549215

DOI

10.1021/acs.inorgchem.2c00371

Scopus ID

2-s2.0-85130862273 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

Linkage isomers are coordination compounds with the same composition but different donor atoms, resulting in distinct physical and electronic structures. A pair of linkage isomers, CuL555 and CuL465, derived from phenylglyoxal bis(ethylthiocarbamate) were synthesized, isolated, and characterized by structural, electrochemical, and spectroscopic methods. The isomers are stable in solution under ambient conditions, but CuL465 converts to CuL555 in acid, consistent with quantum-chemical calculations. The complexes were screened against a lung adenocarcinoma cell line (A549) and a nonmalignant lung fibroblast cell line (IMR-90) to evaluate the antiproliferation activity. CuL555 and CuL465 possessed EC50 values of 0.113 ± 0.030 and 0.115 ± 0.038 μM for A549 and 1.87 ± 0.29 and 0.77 ± 0.22 μM for IMR-90, respectively.

Author List

Bajaj K, Andres SA, Hofsommer DT, Galib M, Mashuta MS, Bennett B, Narayanan B, Buchanan RM, Bates PJ, Grapperhaus CA

Author

Brian Bennett D.Phil. Professor and Chair in the Physics department at Marquette University




MESH terms used to index this publication - Major topics in bold

Copper
Isomerism