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Correlation of plasma angiotensin II concentration and plasma renin activity during acute hypoxia in dogs. Clin Exp Pharmacol Physiol 1985 Jan-Feb;12(1):91-4

Date

01/01/1985

Pubmed ID

2988837

DOI

10.1111/j.1440-1681.1985.tb00307.x

Scopus ID

2-s2.0-0021842018   13 Citations

Abstract

The effects of isocapnic hypoxia on plasma renin activity (PRA) and angiotensin II (AII) concentration were studied in anaesthetized, artificially ventilated dogs. Regression analysis of plasma AII concentration vs PRA, both measured by radioimmunoassay (RIA), was used as an index of converting enzyme activity in vivo. PaO2 decreased from 82 to 30 mmHg but regression analysis did not reveal any inhibition of AII production within the limits of detection of this method (less than 20% inhibition). We conclude that systemic converting enzyme activity, assessed by in vivo measurement and correlation of PRA and AII, is not inhibited by severe hypoxia.

Author List

Raff H, Maselli J, Reid IA

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acute Disease
Angiotensin II
Animals
Dogs
Hypoxia
Lung
Peptidyl-Dipeptidase A
Radioimmunoassay
Renin
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d