The role of H3K9 acetylation and gene expression in different brain regions of Alzheimer's disease patients. Epigenomics 2022 Jun;14(11):651-670
Date
05/20/2022Pubmed ID
35588246DOI
10.2217/epi-2022-0096Scopus ID
2-s2.0-85131772328 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Aims: To evaluate H3K9 acetylation and gene expression profiles in three brain regions of Alzheimer's disease (AD) patients and elderly controls, and to identify AD region-specific abnormalities. Methods: Brain samples of auditory cortex, hippocampus and cerebellum from AD patients and controls underwent chromatin immunoprecipitation sequencing, RNA sequencing and network analyses. Results: We found a hyperacetylation of AD cerebellum and a slight hypoacetylation of AD hippocampus. The transcriptome revealed differentially expressed genes in the hippocampus and auditory cortex. Network analysis revealed Rho GTPase-mediated mechanisms. Conclusions: These findings suggest that some crucial mechanisms, such as Rho GTPase activity and cytoskeletal organization, are differentially dysregulated in brain regions of AD patients at the epigenetic and transcriptomic levels, and might contribute toward future research on AD pathogenesis.
Author List
Santana DA, Bedrat A, Puga RD, Turecki G, Mechawar N, Faria TC, Gigek CO, Payão SL, Smith MA, Lemos B, Chen ESAuthor
Amina Bedrat PhD Postdoctoral Researcher 3 in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetylationAged
Alzheimer Disease
Brain
Humans
Transcriptome
rho GTP-Binding Proteins
