Faculty Collaboration Database

The surgical treatment of medullary thyroid carcinoma. Semin Surg Oncol 1999;16(1):50-63

Date

01/16/1999

Pubmed ID

9890740

DOI

10.1002/(sici)1098-2388(199901/02)16:1<50::aid-ssu9>3.0.co;2-6

Scopus ID

2-s2.0-0031782893 (requires institutional sign-in at Scopus site)   56 Citations

Abstract

Medullary thyroid carcinoma (MTC) is a unique disease in solid tumor oncology due to its ability to secrete calcitonin (iCT), a highly sensitive and specific serum marker of persistent or recurrent disease even at a microscopic level. The relatively long duration of survival experienced by most patients with MTC combined with the visible nature of surgical complications, when they occur, has caused most surgeons to take a conservative approach to the operative management and follow-up of patients with MTC. In contrast, the patient, family physician, and endocrinologist watch the iCT slowly rise, indicative of persistent and usually progressive invasive cancer. Amidst this clinical dilemma, we developed a standardized diagnostic and operative strategy to maximize local-regional tumor control and facilitate patient management.

Author List

Evans DB, Fleming JB, Lee JE, Cote G, Gagel RF

Author

Douglas B. Evans MD Chair, Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Calcitonin
Carcinoma, Medullary
Humans
Multiple Endocrine Neoplasia Type 2a
Multiple Endocrine Neoplasia Type 2b
Neck Dissection
Neoplasm Recurrence, Local
Radiotherapy, Adjuvant
Thyroid Neoplasms
Thyroidectomy