Functional genomics of chlorine-induced acute lung injury in mice. Proc Am Thorac Soc 2010 Jul;7(4):294-6
Date
07/06/2010Pubmed ID
20601635Pubmed Central ID
PMC3136967DOI
10.1513/pats.201001-005SMScopus ID
2-s2.0-77957903593 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Acute lung injury can be induced indirectly (e.g., sepsis) or directly (e.g., chlorine inhalation). Because treatment is still limited to supportive measures, mortality remains high ( approximately 74,500 deaths/yr). In the past, accidental (railroad derailments) and intentional (Iraq terrorism) chlorine exposures have led to deaths and hospitalizations from acute lung injury. To better understand the molecular events controlling chlorine-induced acute lung injury, we have developed a functional genomics approach using inbred mice strains. Various mouse strains were exposed to chlorine (45 ppm x 24 h) and survival was monitored. The most divergent strains varied by more than threefold in mean survival time, supporting the likelihood of an underlying genetic basis of susceptibility. These divergent strains are excellent models for additional genetic analysis to identify critical candidate genes controlling chlorine-induced acute lung injury. Gene-targeted mice then could be used to test the functional significance of susceptibility candidate genes, which could be valuable in revealing novel insights into the biology of acute lung injury.
Author List
Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga LJ, Kaminski N, You M, Prows DRMESH terms used to index this publication - Major topics in bold
AnimalsChlorine
Female
Gases
Genetic Predisposition to Disease
Genomics
Inhalation Exposure
Lung
Lung Diseases
Mice
Mice, Inbred Strains
Models, Animal