Medical College of Wisconsin
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PharmVar GeneFocus: CYP2D6. Clin Pharmacol Ther 2020 Jan;107(1):154-170

Date

09/24/2019

Pubmed ID

31544239

Pubmed Central ID

PMC6925641

DOI

10.1002/cpt.1643

Scopus ID

2-s2.0-85074610699 (requires institutional sign-in at Scopus site)   228 Citations

Abstract

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Author List

Nofziger C, Turner AJ, Sangkuhl K, Whirl-Carrillo M, Agúndez JAG, Black JL, Dunnenberger HM, Ruano G, Kennedy MA, Phillips MS, Hachad H, Klein TE, Gaedigk A

Author

Amy Turner Research Scientist I in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cytochrome P-450 CYP2D6
Databases, Genetic
Genetic Variation
Humans
Knowledge Bases
Pharmaceutical Preparations
Pharmacogenetics
Polymorphism, Genetic