Faculty Collaboration Database

Contributions of central and peripheral chemoreceptors to the ventilatory response to CO2/H+. J Appl Physiol (1985) 2010 Apr;108(4):989-94

Date

01/16/2010

Pubmed ID

20075260

Pubmed Central ID

PMC2853205

DOI

10.1152/japplphysiol.01059.2009

Scopus ID

2-s2.0-77950581249 (requires institutional sign-in at Scopus site)   76 Citations

Abstract

The major objective of this review is to evaluate existing information and reach conclusions regarding whether there is interaction between P(CO(2))/H(+) stimulation of carotid (peripheral) and intracranial (central) chemoreceptors. Interaction is defined as a ventilatory response to simultaneous changes in the degree of Pco2/H(+) stimulation of both chemoreceptors that is greater (hyperadditive) or less (hypoadditive) than the sum of the responses when stimulation of each set of chemoreceptors is individually altered. Simple summation of the simultaneous changes in stimuli results in no interaction (i.e., additive interaction). Knowledge of the nature of central/peripheral interaction is crucial for determining the physiological significance of newer models of ventilatory control based on recent neuroanatomic observations of the circuitry of key elements of the ventilatory control system. In this review, we will propose that these two sets of receptors are not functionally separate but rather that they are dependent on one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the peripheral chemoreceptors and possibly other breathing-related reflex afferents as well. The short format of this minireview demands that we be somewhat selective in developing our ideas. We will briefly discuss the limitations of experiments used to study CO(2)/H(+) sensitivity and interaction to date, traditional views of the relative contributions of peripheral and central chemoreceptors to CO(2)/H(+) sensitivity, the evidence for and against different types of interaction, and the effect of tonic carotid chemoreceptor afferent activity on central control mechanisms.

Author List

Forster HV, Smith CA

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Carbon Dioxide
Carotid Body
Central Nervous System
Disease Models, Animal
Goats
Humans
Peripheral Nervous System
Pulmonary Ventilation
Receptors, Cell Surface