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Xenograft bioprosthetic heart valves: Past, present and future. Int J Surg 2015 Nov;23(Pt B):280-284

Date

07/21/2015

Pubmed ID

26190838

DOI

10.1016/j.ijsu.2015.07.009

Scopus ID

2-s2.0-84951573643   89 Citations

Abstract

The transplantation (implantation) of xenograft heart valves into humans has been carried out for >50 years. There has been considerable research into making this form of xenotransplantation successful, though it is not perfect yet. We review the understanding of the immune response to xenograft heart valves. Important steps in the history include understanding (i) the importance of glutaraldehyde in decreasing the immune response and (ii) the relationship between calcification (which is the main problem leading to xenograft failure) and the immune response. We subsequently discuss the importance of identifying xenoantigens that are important in leading to xenograft valve failure, and the potential of genetically-engineered pigs to allow the development of the 'ideal' heart valve for clinical valve replacement.

Author List

Manji RA, Lee W, Cooper DKC

Author

Whayoung Lee MD Assistant Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Animals, Genetically Modified
Bioprosthesis
Calcinosis
Graft Rejection
Heart Valve Diseases
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Heterografts
Humans
Swine