Faculty Collaboration Database

Negative chronotropic factor in patients with fungemia. Crit Care Med 1992 Mar;20(3):327-31

Date

03/01/1992

Pubmed ID

1541092

DOI

10.1097/00003246-199203000-00006

Scopus ID

2-s2.0-0026560129 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

OBJECTIVE: To study the effect of serum from patients with fungemia and control patients on sinoatrial node function.

DESIGN: Prospective, observational study.

SETTING: Surgical ICU in a university hospital.

PATIENTS: Fourteen patients with fungemia and 14 control patients.

MEASUREMENTS AND MAIN RESULTS: Serum samples from all patients were assayed in an in vitro sinus node preparation. Serum samples from 11 (78%) of the 14 fungemic patients caused a decrease in sinus node activity, while serum samples from only one (7%) of 14 control patients caused slowing of the sinus node.

CONCLUSIONS: Serum from many patients with fungemia causes slowing of an in vitro sinus node preparation. This in vitro finding may explain bradyarrhythmias seen clinically in the setting of fungemia.

Author List

Rosenfeld BA, Bosnjak ZJ, Shapiro RM, Dorman T, Ligier B, Breslow MJ

MESH terms used to index this publication - Major topics in bold

Action Potentials
Adult
Aged
Aged, 80 and over
Bacteremia
Bradycardia
Candidiasis
Female
Fungemia
Humans
Intensive Care Units
Male
Middle Aged
Sinoatrial Node