Structure-based studies of chemokine receptors. Curr Opin Struct Biol 2013 Aug;23(4):539-46
Date
05/28/2013Pubmed ID
23706951DOI
10.1016/j.sbi.2013.05.003Scopus ID
2-s2.0-84881112796 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Chemokine receptors, which belong to the G protein-coupled receptor (GPCR) family of proteins, are critical regulators of cell migration in the context of immune surveillance, inflammation, and development. Recently determined structures of chemokine receptor CXCR4 reveal unique structural features, and offer templates for homology modeling of other chemokine receptors, which deepen our understanding in ligand-binding modes and signal transduction mechanisms. Dimerization, another intriguing issue for GPCR research, is also reviewed based on all published GPCR structures.
Author List
Zhu L, Zhao Q, Wu BAuthor
Lan Zhu PhD Assistant Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Binding SitesCell Movement
Computer Simulation
Crystallography, X-Ray
Dimerization
High-Throughput Screening Assays
Humans
Ligands
Models, Molecular
Protein Binding
Protein Conformation
Receptors, CXCR4
