Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development. Gastroenterology 2021 Jan;160(2):495-506
Date
12/12/2020Pubmed ID
33307032Pubmed Central ID
PMC8714606DOI
10.1053/j.gastro.2020.08.065Scopus ID
2-s2.0-85099680987 (requires institutional sign-in at Scopus site) 75 CitationsAbstract
The composition of the intestinal microbiome affects health from the prenatal period throughout childhood, and many diseases have been associated with dysbiosis. The gut microbiome is constantly changing, from birth throughout adulthood, and several variables affect its development and content. Features of the intestinal microbiota can affect development of the brain, immune system, and lungs, as well as body growth. We review the development of the gut microbiome, proponents of dysbiosis, and interactions of the microbiota with other organs. The gut microbiome should be thought of as an organ system that has important effects on childhood development. Dysbiosis has been associated with diseases in children and adults, including autism, attention deficit hyperactivity disorder, asthma, and allergies.
Author List
Ronan V, Yeasin R, Claud ECAuthor
Victoria Ronan MBBS Assistant Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentBody Weight
Central Nervous System
Child
Child Development
Child, Preschool
Dysbiosis
Environment
Female
Gastrointestinal Microbiome
Health
Health Status
Humans
Immune System
Infant
Infant, Newborn
Lung
