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A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun (Camb) 2019 May 09;55(39):5551-5554

Date

04/12/2019

Pubmed ID

30972394

DOI

10.1039/c9cc02021g

Scopus ID

2-s2.0-85065665479 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.

Author List

Duggirala NK , Li J , Kumar NSK , Gopinath T , Suryanarayanan R

Author

Gopinath Tata PhD Assistant Professor in the Biophysics department at Medical College of Wisconsin