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Microsatellite instability in in situ and invasive sporadic breast cancers of Japanese women. Cancer Lett 1996 Nov 29;108(2):205-9

Date

11/29/1996

Pubmed ID

8973596

DOI

10.1016/s0304-3835(96)04414-x

Scopus ID

2-s2.0-0030606263   21 Citations

Abstract

We studied the timing of microsatellite instability (referred to as replication error; RER) presentation during human breast carcinogenesis using tissue microdissected from both in situ and invasive breast cancers of Japanese women. We analyzed 100 breast cancer specimens for RER at nine genomic loci on seven chromosomes. Eight of the 100 cases (8%) were RER-positive at one or more chromosomal loci. Additionally; we obtained genomic DNA from two of four RER-positive patients with an intraductal component, both of which showed microsatellite instability in in situ foci. This finding indicates that microsatellite instability may be an early event during human breast carcinogenesis.

Author List

Toyama T, Iwase H, Iwata H, Hara Y, Omoto Y, Suchi M, Kato T, Nakamura T, Kobayashi S

Author

Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Breast Neoplasms
Carcinoma in Situ
Carcinoma, Ductal, Breast
DNA, Satellite
Female
Humans
Microsatellite Repeats
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a