A Rare Case of Acne Medication-Induced Drug Reaction With Eosinophilia and Systemic Symptoms. WMJ 2022 Oct;121(3):E53-E56
Date
10/28/2022Pubmed ID
36301660Scopus ID
2-s2.0-85140864932 (requires institutional sign-in at Scopus site) 1 CitationAbstract
INTRODUCTION: Acne vulgaris is the most common skin condition in late adolescence and frequently requires systemic treatment with antibiotics or androgen receptor blockers in moderateto- severe cases.
CASE PRESENTATION: We report the case of a 17-year-old adolescent female with new onset fever, headache, and pruritic rash 1 month after she started doxycycline and spironolactone for the treatment of acne vulgaris. Later, she developed eosinophilia and transaminitis. Infectious workup was negative.
DISCUSSION: This presentation was consistent with a definite case of drug reaction with eosinophilia and systemic symptoms (DRESS). DRESS is a severe, systemic hypersensitivity drug reaction that typically occurs 2 to 8 weeks following exposure to the offending medication.
CONCLUSIONS: Although doxycycline and spironolactone are uncommon triggers of DRESS, they are common medications used to treat acne, and clinicians should be aware of this potential complication when counseling patients, especially adolescents.
Author List
Hamel BL, Mason SF, Burek AG, Holland KEAuthors
Alina G. Burek MD Assistant Professor in the Pediatrics department at Medical College of WisconsinKristen E. Holland MD Associate Professor in the Dermatology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Acne VulgarisAged
Diuretics
Drug Hypersensitivity Syndrome
Female
Humans
Hyponatremia
Sodium
Trimethoprim, Sulfamethoxazole Drug Combination
