Metabolic Reprogramming in Tumor-Associated Macrophages in the Ovarian Tumor Microenvironment. Cancers (Basel) 2022 Oct 25;14(21)
Date
11/12/2022Pubmed ID
36358644Pubmed Central ID
PMC9656653DOI
10.3390/cancers14215224Scopus ID
2-s2.0-85141848301 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
The interaction between tumor cells and macrophages in the tumor microenvironment plays an essential role in metabolic changes in macrophages and reprograms them towards a pro-tumorigenic phenotype. Increasing evidence indicates that macrophage metabolism is a highly complex process and may not be as simple as previously thought. Pro-inflammatory stimuli switch macrophages towards an M1-like phenotype and rely mainly on aerobic glycolysis and fatty acid synthesis, whereas anti-inflammatory stimuli switch macrophages towards an M2-like phenotype. M2-like macrophages depend more on oxidative phosphorylation (OXPHOS) and fatty acid oxidation. However, this metabolically reprogrammed phenotypic switch in macrophages remained a mystery for a while. Therefore, through this review, we tend to describe how macrophage immunometabolism determines macrophage phenotypes and functions in tumor microenvironments (TMEs). Furthermore, we have discussed how metabolic reprogramming in TAM can be used for therapeutic intervention and drug resistance in ovarian cancer.
Author List
Kumar S, Mittal S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep SAuthors
Pradeep Chaluvally-Raghavan PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of WisconsinFNU Mona PhD Postdoctoral Researcher 2 in the Obstetrics and Gynecology department at Medical College of Wisconsin
Sunila Pradeep PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
