Faculty Collaboration Database

The visual system of zebrafish and its use to model human ocular diseases. Dev Neurobiol 2012 Mar;72(3):302-27

Date

05/20/2011

Pubmed ID

21595048

Pubmed Central ID

PMC3202066

DOI

10.1002/dneu.20919

Scopus ID

2-s2.0-84856959269   75 Citations

Abstract

Free swimming zebrafish larvae depend mainly on their sense of vision to evade predation and to catch prey. Hence, there is strong selective pressure on the fast maturation of visual function and indeed the visual system already supports a number of visually driven behaviors in the newly hatched larvae.The ability to exploit the genetic and embryonic accessibility of the zebrafish in combination with a behavioral assessment of visual system function has made the zebrafish a popular model to study vision and its diseases.Here, we review the anatomy, physiology, and development of the zebrafish eye as the basis to relate the contributions of the zebrafish to our understanding of human ocular diseases.

Author List

Gestri G, Link BA, Neuhauss SC

Author

Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Eye
Eye Diseases
Humans
Morphogenesis
Visual Pathways
Zebrafish