Faculty Collaboration Database

Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery. Adipocyte 2017 Apr 03;6(2):134-140

Date

04/21/2017

Pubmed ID

28425841

Pubmed Central ID

PMC5477697

DOI

10.1080/21623945.2017.1287639

Scopus ID

2-s2.0-85050578200 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

Predictors of weight loss responses are not well-defined. We hypothesized that adipose tissue phenotypic features related to remodeling would be associated with bariatric surgery weight loss responses. Visceral and subcutaneous adipose tissues collected from patients during bariatric surgery were studied with flow cytometry, immunohistochemistry, and QRTPCR, and results correlated with weight loss outcomes. Age, male sex, and a diagnosis of type 2 diabetes were associated with less weight loss. Adipocyte size was increased and preadipocyte frequency was decreased in visceral adipose tissue from diabetic subjects. Decreased adipose tissue preadipocyte frequency was associated with less weight loss in women but not men. These data suggest that phenotypic features of adipose tissue remodeling may predict responses to weight loss interventions.

Author List

Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka LM, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O'Rourke RW

Author

Amir Ghaferi MD President, Phys Enterprise & SAD Clinical Affairs in the Medical College Physicians Administration department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adipocytes
Adipose Tissue
Adiposity
Bariatric Surgery
Female
Humans
Hyperplasia
Hypertrophy
Intra-Abdominal Fat
Male
Obesity
Subcutaneous Fat
Treatment Outcome
Weight Loss