Progression of diabetic retinopathy after endophthalmitis. Ophthalmology 1999 Apr;106(4):774-81
Date
04/14/1999Pubmed ID
10201602DOI
10.1016/S0161-6420(99)90166-5Scopus ID
2-s2.0-0033505621 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
OBJECTIVE: To determine the effect of endophthalmitis on diabetic retinopathy.
DESIGN: Noncomparative case series.
METHODS: The records of all consecutive patients with endophthalmitis treated between 1992 and 1997 at the Medical College of Wisconsin were retrospectively reviewed. Those patients with diabetes mellitus were analyzed.
PARTICIPANTS: From 77 reviewed records, 11 patients (12 eyes; 14%) were identified as diabetics with endophthalmitis and were studied.
MAIN OUTCOME MEASURES: Stage of diabetic retinopathy, time to retinopathy progression, and visual acuity.
RESULTS: Mean patient age was 68 years, and mean duration of diabetes was 11.7 years. Mean patient follow-up was 17 months. Of the six cases without evidence of retinopathy before the endophthalmitis, none went on to develop retinopathy. Of six eyes with pre-existing nonproliferative retinopathy, four showed evidence of progression within 6 months of the infection. Three developed severe proliferative disease and macular edema, and one developed severe nonproliferative disease. More patients without pre-existing retinopathy achieved a final visual acuity of 20/40 or greater.
CONCLUSIONS: Patients with pre-existing diabetic retinopathy may be at increased risk for rapid retinopathy progression and a poorer visual outcome after endophthalmitis. These results support the concept that inflammation may exacerbate diabetic retinopathy.
Author List
Dev S, Pulido JS, Tessler HH, Mittra RA, Han DP, Mieler WF, Connor TB JrAuthor
Thomas B. Connor MD Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Diabetic Retinopathy
Disease Progression
Endophthalmitis
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retrospective Studies
Time Factors
Visual Acuity
