Faculty Collaboration Database

Epidemiology and treatment of melanoma in elderly patients. Nat Rev Clin Oncol 2010 Mar;7(3):148-52

Date

02/10/2010

Pubmed ID

20142815

DOI

10.1038/nrclinonc.2010.1

Scopus ID

2-s2.0-77949275842 (requires institutional sign-in at Scopus site)   63 Citations

Abstract

The number of melanoma cases in the elderly (>65 years) will rise over the coming decades, making it an important public health problem. Elderly white men are the demographic group who are at highest risk of being diagnosed with melanoma and of dying from this cancer. Among patients with melanoma, older age is recognized as an independent poor prognostic factor, but it remains unclear whether this relationship is due to a change in the biology of the disease with increasing patient age, declining host defenses, or both. Most elderly patients can have surgery to control locoregional disease, but might not be candidates for intensive biologic therapies for advanced melanoma because of comorbidities and inability to tolerate the adverse side effects of these treatments. Early detection remains an important strategy for the management of melanoma. Further research is needed to determine why older melanoma patients have a worse prognosis than their younger counterparts, even when matched for all other clinical and pathological predictors of survival outcomes.

Author List

Tsai S, Balch C, Lange J

MESH terms used to index this publication - Major topics in bold

Aged
Humans
Male
Melanoma
Treatment Outcome