Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase α-Deficient Mice. J Immunol 2023 May 01;210(9):1281-1291
Date
03/16/2023Pubmed ID
36920384Pubmed Central ID
PMC10121876DOI
10.4049/jimmunol.2101011Scopus ID
2-s2.0-85152632053 (requires institutional sign-in at Scopus site)Abstract
Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is regulated by enzymatic degradation by diacylglycerol kinases (DGKs). In T cells, stringent regulation of the activity of this second messenger maintains an appropriate balance between effector function and anergy. In this article, we demonstrate that DGKα is an indispensable regulator of TCR-mediated activation of CD8 T cells in lymphocytic choriomeningitis virus Clone 13 viral infection. In the absence of DGKα, Clone 13 infection in a murine model results in a pathologic, proinflammatory state and a multicellular immunopathologic host death that is predominantly driven by CD8 effector T cells.
Author List
Kudek MR, Xin G, Alson D, Holzhauer S, Shen J, Kasmani MY, Riese M, Cui WAuthors
Donia Alson Postdoctoral Researcher 2 in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMatthew Kudek MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsCD8-Positive T-Lymphocytes
Clone Cells
Diacylglycerol Kinase
Diglycerides
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus
Mice
Mice, Inbred C57BL
Mice, Knockout
