Faculty Collaboration Database

Preoperative n-BCA embolization in the resection of submandibular lymphatic malformations refractory to sclerotherapy treatment: A pilot case series. Int J Pediatr Otorhinolaryngol 2023 May;168:111510

Date

04/02/2023

Pubmed ID

37003014

DOI

10.1016/j.ijporl.2023.111510

Scopus ID

2-s2.0-85151488542 (requires institutional sign-in at Scopus site)

Abstract

OBJECTIVE: Lymphatic malformations in the submandibular neck pose unique challenges to treatment that elevate their risk of recurrence. This case series provides a review of five patients, previously treated with sclerotherapy or with a history of multiple infections, who were treated in a novel fashion: single-stage resection using preoperative n-butyl cyanoacrylate (n-BCA) glue embolization.

METHODS: We performed a retrospective medical record review of five patients who underwent single-stage n-BCA embolization by Interventional Radiology followed by surgical resection by Otolaryngology, including a review of their symptoms, previous treatments, and post-treatment surveillance, with follow-up ranging from 4 to 24 months after the treatment of interest.

RESULTS: All study subjects had unremarkable perioperative courses, and four patients did not demonstrate any evidence of disease recurrence or persistence during the follow-up period. One patient was found to have a small area of persistent disease on post-treatment imaging, but has remained symptom free.

CONCLUSIONS: Treatment of submandibular lymphatic malformations with n-BCA embolization followed by surgical resection can be performed in a single stage. This case series demonstrates that this approach can yield durable relief of symptoms, even in patients whose lesions were refractory to previous treatments.

Author List

Shum A, Beydoun AS, Khalifee E, Carlberg V, Plunk M, Chun R

Authors

Valerie M. Carlberg MD Associate Professor in the Dermatology department at Medical College of Wisconsin
Robert H. Chun MD Professor in the Otolaryngology department at Medical College of Wisconsin
Axel Shum MD Assistant Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Embolization, Therapeutic
Enbucrilate
Humans
Lymphatic Abnormalities
Neck
Retrospective Studies
Sclerotherapy
Treatment Outcome