Induced hypothermia in acute ischemic stroke. Expert Opin Investig Drugs 2008 Aug;17(8):1161-74
Date
07/12/2008Pubmed ID
18616413DOI
10.1517/13543784.17.8.1161Scopus ID
2-s2.0-51449107899 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
BACKGROUND: Induced hypothermia is a promising neuroprotective treatment for acute ischemic stroke. Data from both global and focal ischemia animal models have been encouraging. However, only a few small clinical studies have investigated its use in humans.
OBJECTIVE: To review the background, possible mechanisms of action, and the preclinical and clinical data supporting the neuroprotective role of induced hypothermia following acute ischemic stroke.
METHODS: A literature search was performed using the PubMed database. Only papers in English were reviewed.
RESULTS/CONCLUSIONS: Induced hypothermia is effective as a neuroprotectant in animal models of acute ischemic stroke. Its multimodal mechanism of action makes it a very attractive method of neuroprotection. Although human studies suggest it is safe and feasible, larger randomized controlled trials are necessary to address clinical efficacy and to refine the methods and parameters of induced hypothermia protocols.
Author List
Lazzaro MA, Prabhakaran SAuthor
Marc A. Lazzaro MD Associate Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAnimals
Blood-Brain Barrier
Brain Ischemia
Clinical Trials as Topic
Humans
Hypothermia, Induced
Stroke
Treatment Outcome
