Cancer's craving for sugar: an opportunity for clinical exploitation. J Cancer Res Clin Oncol 2009 Jul;135(7):867-77
Date
05/06/2009Pubmed ID
19415328Pubmed Central ID
PMC12160197DOI
10.1007/s00432-009-0590-8Scopus ID
2-s2.0-66949122181 (requires institutional sign-in at Scopus site) 51 CitationsAbstract
More than 80 years ago, Otto Warburg described the phenomenon whereby cancer cells avidly take up glucose and produce lactic acid under aerobic conditions, a process subsequently referred to as the Warburg effect or aerobic glycolysis. The exact molecular mechanisms underlying cancers reliance on glycolysis remains unclear, but is likely a combination of an epigenetic response to the hypoxic tumour environment in combination with direct oncogenic stimulation. The aim of the current manuscript is to review the normal process of glycolysis and highlight the alterations that occur with malignant transformation, to consider the potential advantages of glycolytic respiration for cancer cell survival, and finally to explore areas where altered glucose metabolism can be exploited for clinical benefit.
Author List
Yeluri S, Madhok B, Prasad KR, Quirke P, Jayne DGAuthor
Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Carbohydrate Metabolism
Cell Respiration
Drug Delivery Systems
Glucose
Glycolysis
Humans
Models, Biological
Neoplasms
