Interferon-gamma secretion defects in haemophilia A patients receiving highly purified plasma-derived or recombinant factor VIII. Br J Haematol 1996 Dec;95(3):554-60
Date
12/01/1996Pubmed ID
8943901DOI
10.1046/j.1365-2141.1996.d01-1924.xScopus ID
2-s2.0-0029859034 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The outcome of developing immune responses is influenced by interactions among a large and complex network of secreted cytokines. T-cell secretion of interferon-gamma (IFN-gamma), tumour necrosis factor alpha (TNF-alpha) and TNF-beta, or lymphotoxin contributes to the development of cell-mediated immunity, whereas secretion of interleukin (IL)-4, IL-5 and IL-6 contributes to development of humoral immunity. Humoral immunity to factor VIII (FVIII) develops in approximately 25% of severe haemophilia A patients. The aim of our research was to understand the underlying immune response to FVIII in patients with FVIII inhibitors. We report a defect in IFN-gamma secretion by peripheral blood mononuclear cells (PBMC) derived from haemophilia A patients, which was accompanied by a low level of mitogen-induced proliferation and a significant decrease in the percentage of natural killer (NK) cells. All of the observed defects were found in haemophilia A patients, both with and without FVIII inhibitors, who were free of viral infection and had been treated predominantly or exclusively with monoclonal antibody-purified or recombinant FVIII.
Author List
Newton-Nash DK, Tollerud D, Guevarra L, Gill JCAuthor
Debra K. Newman PhD Investigator in the Blood Research Institute department at BloodCenter of WisconsinMESH terms used to index this publication - Major topics in bold
Child, PreschoolFactor VIII
Granulocyte-Macrophage Colony-Stimulating Factor
Hemophilia A
Humans
Infant
Interferon-gamma
Killer Cells, Natural
T-Lymphocytes