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Hepatic hemangioendothelioma: successful treatment with steroid in a very-low-birth-weight infant. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1996 Jan-Feb;37(1):56-8



Pubmed ID


Scopus ID

2-s2.0-0029680371   5 Citations


A female infant, born at the gestational age of 29 weeks with a birthweight of 1,350 gm, developed progressive hepatomegaly at 10 days of age. Congestive heart failure gradually developed, and hepatic hemangioendothelioma was diagnosed at 1 month of age by open biopsy. Due to rapid enlargement of the tumor and progressive heart failure, steroid therapy was given from 36 days of age, including methylprednisolone 15 mg/kg/day for 3 days and 10 mg/kg/day for 4 days, then prednisolone 4 mg/kg/day for 20 days followed by tapering till 74 days of age. The tumor regressed gradually and was not detectable by sonography at 33 months of age. We suggest that, even in very-low-birthweight infants, the prognosis of hepatic hemangioendothelioma may be improved with aggressive therapy when symptoms develop during tumor progression, and that steroid should be the initial treatment.

Author List

Wu TJ, Teng RJ, Tsou Yau KI


Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tzong-Jin Wu MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Dose-Response Relationship, Drug
Drug Administration Schedule
Infant, Newborn
Infant, Premature, Diseases
Infant, Very Low Birth Weight
Liver Neoplasms
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0