Faculty Collaboration Database

Monte Carlo framework for commissioning a synchrotron-based discrete spot scanning proton beam system and treatment plan verification. Biomed Phys Eng Express 2021 Jun 10;7(4)

Date

06/03/2021

Pubmed ID

34077921

DOI

10.1088/2057-1976/ac077a

Scopus ID

2-s2.0-85108124200 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

This study aimed to develop a Monte Carlo (MC) framework for commissioning the narrow proton beams (spot size sigma, 5.2 mm 2 mm at isocenter for 69.4 MeV-221.3 MeV for the main beam option and 4.1 mm 1.3 mm for the minibeam option respectively) of a synchrotron-based proton therapy system and design an independent absolute dose calculation engine for intensity-modulated proton treatments. A proton therapy system (Hitachi PROBEAT-V) was simulated using divergent and convergent beam models at the nozzle entrance. The innovative source weighting scheme for the MC simulation with TOPAS (TOol for PArticle Simulations) was implemented using dose output data for the absolute dose calculations. The results of the MC simulation were compared to the experimental data, analyzed and used to commission the treatment planning system. Two MC models, divergent and convergent beams were implemented. The convergent beam model produced a high level of agreement when MC and measurements were analyzed. The beam ellipticity did not result in significant differences between MC simulated and treatment planning system calculated doses. A model of a synchrotron-based spot scanning proton therapy system has been developed and implemented in the TOPAS MC transport code framework. The dose computation engine is useful for treatment plan verification with primary and minibeam beam option.

Author List

Moskvin VP, Faught A, Pirlepesov F, Zhao L, Hua CH, Merchant TE

Author

Li Zhao PhD Associate Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Phantoms, Imaging
Protons
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Synchrotrons