The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons. J Neurosci 1997 Jun 01;17(11):4398-405
Date
06/01/1997Pubmed ID
9151756Pubmed Central ID
PMC6573523DOI
10.1523/JNEUROSCI.17-11-04398.1997Scopus ID
2-s2.0-0030979272 (requires institutional sign-in at Scopus site) 61 CitationsAbstract
Mice with a targeted deletion of the low-affinity neurotrophin receptor p75 (p75-/-) exhibit a 50% loss of large- and small-diameter sensory neurons in the dorsal root ganglion. Using neurophysiological recording techniques, we now show that p75 is not required for the survival of specific, functionally defined subpopulations of sensory neurons. Rather, p75-/- mice exhibit losses of neurons that subserve nociceptive as well as non-nociceptive functions. The receptive properties of large myelinated afferent fibers were normal in p75-/- mice. However, the receptive properties of subpopulations of afferent fibers with thin myelinated or unmyelinated axons were strikingly impaired in mice lacking p75. Furthermore, the presence of p75 is required for normal mechanotransduction in C fibers and D-hair receptors and normal heat sensitivity in A-fiber nociceptors.
Author List
Stucky CL, Koltzenburg MAuthor
Cheryl L. Stucky PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApoptosis
Cell Survival
Cold Temperature
Electric Stimulation
Electrophysiology
Female
Ganglia, Spinal
Glial Cell Line-Derived Neurotrophic Factor
Homozygote
Hot Temperature
Male
Mechanoreceptors
Mice
Mice, Inbred BALB C
Mice, Transgenic
Mutagenesis
Nerve Growth Factors
Nerve Tissue Proteins
Neurons, Afferent
Neuroprotective Agents
Neurotrophin 3
Nociceptors
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor
Sensory Thresholds
