Functional MRI is a valid noninvasive alternative to Wada testing. Epilepsy Behav 2011 Feb;20(2):214-22
Date
09/21/2010Pubmed ID
20850386Pubmed Central ID
PMC3008762DOI
10.1016/j.yebeh.2010.08.004Scopus ID
2-s2.0-79951681505 (requires institutional sign-in at Scopus site) 146 CitationsAbstract
Partial removal of the anterior temporal lobe (ATL) is a highly effective surgical treatment for intractable temporal lobe epilepsy, yet roughly half of patients who undergo left ATL resection show a decline in language or verbal memory function postoperatively. Two recent studies demonstrate that preoperative fMRI can predict postoperative naming and verbal memory changes in such patients. Most importantly, fMRI significantly improves the accuracy of prediction relative to other noninvasive measures used alone. Addition of language and memory lateralization data from the intracarotid amobarbital (Wada) test did not improve prediction accuracy in these studies. Thus, fMRI provides patients and practitioners with a safe, noninvasive, and well-validated tool for making better-informed decisions regarding elective surgery based on a quantitative assessment of cognitive risk.
Author List
Binder JRAuthor
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BrainEpilepsy, Temporal Lobe
Functional Laterality
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Memory
Oxygen
Predictive Value of Tests
Verbal Learning
