Single neuron responses underlying face recognition in the human midfusiform face-selective cortex. Nat Commun 2023 Sep 13;14(1):5661
Date
09/14/2023Pubmed ID
37704636Pubmed Central ID
PMC10499913DOI
10.1038/s41467-023-41323-5Scopus ID
2-s2.0-85170830231 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Faces are critical for social interactions and their recognition constitutes one of the most important and challenging functions of the human brain. While neurons responding selectively to faces have been recorded for decades in the monkey brain, face-selective neural activations have been reported with neuroimaging primarily in the human midfusiform gyrus. Yet, the cellular mechanisms producing selective responses to faces in this hominoid neuroanatomical structure remain unknown. Here we report single neuron recordings performed in 5 human subjects (1 male, 4 females) implanted with intracerebral microelectrodes in the face-selective midfusiform gyrus, while they viewed pictures of familiar and unknown faces and places. We observed similar responses to faces and places at the single cell level, but a significantly higher number of neurons responding to faces, thus offering a mechanistic account for the face-selective activations observed in this region. Although individual neurons did not respond preferentially to familiar faces, a population level analysis could consistently determine whether or not the faces (but not the places) were familiar, only about 50 ms after the initial recognition of the stimuli as faces. These results provide insights into the neural mechanisms of face processing in the human brain.
Author List
Quian Quiroga R, Boscaglia M, Jonas J, Rey HG, Yan X, Maillard L, Colnat-Coulbois S, Koessler L, Rossion BAuthor
Hernan Gonzalo Rey PhD Assistant Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BrainCerebral Cortex
Endocrine Glands
Facial Recognition
Female
Humans
Male
Neurons
