Medical College of Wisconsin
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Altered stability of dynamic brain functional architecture in primary open-angle glaucoma: a surface-based resting-state fMRI study. Brain Imaging Behav 2024 Feb;18(1):44-56

Date

10/20/2023

Pubmed ID

37857914

Pubmed Central ID

PMC10844345

DOI

10.1007/s11682-023-00800-7

Scopus ID

2-s2.0-85174412971 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

Delineating the neuropathological characteristics of primary open-angle glaucoma (POAG) is critical for understanding its pathophysiology. While temporal stability represents a crucial aspect of the brain's functional architecture, the specific patterns underlying its contribution to POAG remain unclear. This study aims to analyze the brain functional abnormalities in POAG using functional stability, a dynamic functional connectivity (DFC) approach based on resting-state functional magnetic resonance imaging (rs-fMRI). Seventy patients with POAG and forty-five healthy controls underwent rs-fMRI and ophthalmological examinations. The stability of DFC was calculated as the concordance of DFC over time using a sliding-window approach, and the differences in stability between the two groups were compared. Subsequently, Spearman's correlation analyses were conducted to examine the relationship between functional stability and clinical indicators. Compared with healthy controls, patients with POAG exhibited significantly decreased functional stability in the visual network, including the early visual center, ventral and dorsal stream visual cortex in both hemispheres. Conversely, stability values increased in the bilateral inferior parietal gyrus and right inferior frontal cortex. In POAG patients, the dynamic stability of the left early visual cortex and ventral stream visual cortex correlated with the mean deviation of visual field defects (r = 0.251, p = 0.037). The evidence from this study suggests that functional stability may provide a new understanding of brain alterations in the progression of POAG.

Author List

Yang B, Su M, Wang Q, Qu X, Wang H, Chen W, Sun Y, Li T, Wang Y, Wang N, Xian J

Author

Yang Wang MD Professor in the Radiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Brain
Brain Diseases
Brain Mapping
Glaucoma, Open-Angle
Humans
Magnetic Resonance Imaging