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20-HETE in acute kidney injury. Kidney Int 2011 Jan;79(1):10-3

Date

12/16/2010

Pubmed ID

21157458

Pubmed Central ID

PMC3146060

DOI

10.1038/ki.2010.396

Scopus ID

2-s2.0-78650266984 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

Ischemia/reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) that is associated with a patient mortality of up to 50%. Currently there are not effective pharmacologic therapies for AKI. This Commentary highlights recent evidence indicating that 20-HETE plays an important role in IRI and that drugs that target this pathway have potential as therapeutic agents for AKI.

Author List

Roman RJ, Akbulut T, Park F, Regner KR

Author

Kevin R. Regner MD Interim Chair, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acute Kidney Injury
Animals
Humans
Hydroxyeicosatetraenoic Acids
Rats
Reperfusion Injury