Faculty Collaboration Database

Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization. bioRxiv 2023 Dec 02

Date

12/11/2023

Pubmed ID

38076938

Pubmed Central ID

PMC10705253

DOI

10.1101/2023.01.30.523509

Abstract

We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance of deviations from typical age-related neuroanatomical changes and support future study designs. This framework was developed using regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The Multivariate Factorial Polynomial Regression (MFPR) emerged as the preferred algorithm optimized using nonlinear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins, and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3,000 study participants. The model and scripts described here are freely available through CentileBrain (https://centilebrain.org/).

Author List

Ge R, Yu Y, Qi YX, Fan YV, Chen S, Gao C, Haas SS, Modabbernia A, New F, Agartz I, Asherson P, Ayesa-Arriola R, Banaj N, Banaschewski T, Baumeister S, Bertolino A, Boomsma DI, Borgwardt S, Bourque J, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buckner R, Buitelaar JK, Cannon DM, Caseras X, Cervenka S, Conrod PJ, Crespo-Facorro B, Crivello F, Crone EA, de Haan L, de Zubicaray GI, Di Giorgio A, Erk S, Fisher SE, Franke B, Frodl T, Glahn DC, Grotegerd D, Gruber O, Gruner P, Gur RE, Gur RC, Harrison BJ, Hatton SN, Hickie I, Howells FM, Hulshoff Pol HE, Huyser C, Jernigan TL, Jiang J, Joska JA, Kahn RS, Kalnin AJ, Kochan NA, Koops S, Kuntsi J, Lagopoulos J, Lazaro L, Lebedeva IS, Lochner C, Martin NG, Mazoyer B, McDonald BC, McDonald C, McMahon KL, Nakao T, Nyberg L, Piras F, Portella MJ, Qiu J, Roffman JL, Sachdev PS, Sanford N, Satterthwaite TD, Saykin AJ, Schumann G, Sellgren CM, Sim K, Smoller JW, Soares J, Sommer IE, Spalletta G, Stein DJ, Tamnes CK, Thomopolous SI, Tomyshev AS, Tordesillas-Gutiérrez D, Trollor JN, van 't Ent D, van den Heuvel OA, van Erp TG, van Haren NE, Vecchio D, Veltman DJ, Walter H, Wang Y, Weber B, Wei D, Wen W, Westlye LT, Wierenga LM, Williams SC, Wright MJ, Medland S, Wu MJ, Yu K, Jahanshad N, Thompson PM, Frangou S

Author

Yang Wang MD Professor in the Radiology department at Medical College of Wisconsin