Elevated salt intake impairs dilation of rat skeletal muscle resistance arteries via ANG II suppression. Am J Physiol Heart Circ Physiol 2000 Feb;278(2):H500-6
Date
02/09/2000Pubmed ID
10666081DOI
10.1152/ajpheart.2000.278.2.H500Scopus ID
2-s2.0-0034011528 (requires institutional sign-in at Scopus site) 57 CitationsAbstract
Vasodilator responses were assessed in resistance arteries (100-200 microm) isolated from the gracilis muscle of normotensive rats after changes in dietary salt intake. Sprague-Dawley rats were maintained on either a high-salt (HS) diet (4.0% NaCl) or a low-salt (LS) diet (0.4% NaCl) for 4-8 wk (chronic) or 3 days (short-term) with water ad libitum. One group of short-term HS rats received a continuous intravenous infusion of a low dose (5 ng x kg(-1) x min(-1)) of ANG II to prevent the ANG II suppression that occurs with HS diet. Short-term and chronic HS diet eliminated arterial dilation in response to ACh and reduced PO(2) (30-40 mmHg) and the stable prostacyclin analog iloprost. ANG II infusion preserved the response to these vasodilator stimuli in short-term HS animals. Dilator responses to sodium nitroprusside and forskolin were unaffected by HS diet. These findings suggest that ANG II suppression during HS diet impairs vascular relaxation mechanisms upstream from the cAMP and cGMP second messenger systems.
Author List
Weber DS, Lombard JHMESH terms used to index this publication - Major topics in bold
Angiotensin IIAnimals
Arteries
Blood Pressure
Body Weight
Calcium
Diet, Sodium-Restricted
Male
Muscle, Skeletal
Oxygen
Partial Pressure
Rats
Rats, Sprague-Dawley
Vascular Resistance
Vasodilation
Vasodilator Agents
