Medical College of Wisconsin
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The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation after pars plana vitrectomy with long-acting gas tamponade. Ophthalmology 2000 Mar;107(3):588-92

Date

03/11/2000

Pubmed ID

10711900

DOI

10.1016/s0161-6420(99)00083-4

Scopus ID

2-s2.0-0034080833 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

OBJECTIVE: To determine whether topical aqueous suppressant therapy applied after pars plana vitrectomy with gas tamponade prevents postoperative intraocular pressure (IOP) elevation.

DESIGN: Prospective, nonrandomized comparative study.

PARTICIPANTS: Forty-one patients who met inclusion criteria and underwent pars plana vitrectomy with gas tamponade (SF6 18%-20% or C3F8 12%-16%) over a 1-year period.

INTERVENTION: Treatment eyes received topical aqueous suppressants at the end of surgery.

MAIN OUTCOME MEASURES: Postoperative IOP at 4 to 6 hours, 1 day, and 1 week.

RESULTS: Twenty-one control and 20 treatment eyes met the inclusion criteria. The IOP (in mmHg) measured at 4 to 6 hours (23.05 [control, 14.73 [treatment]) and 1 day (23.24 [control], 17.28 [treatment]) postoperatively showed a statistically significant difference between the groups (P = 0.0038) at 4 to 6 hours and a trend toward significance (P = 0.057) at 1 day. Eleven control and three treatment eyes had an IOP spike above 25 mmHg at 4 to 6 hours or 1 day postoperatively (P = 0.02), and six control eyes and one treatment eye had postoperative IOP greater than 30 mmHg. A pressure rise greater than 40 mmHg was seen in two control eyes and no treatment eyes.

CONCLUSIONS: Use of topical aqueous suppressants after pars plana vitrectomy with long-acting gas tamponade is effective in preventing significant postoperative IOP elevation in most cases.

Author List

Mittra RA, Pollack JS, Dev S, Han DP, Mieler WF, Pulido JS, Connor TB

Author

Thomas B. Connor MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Administration, Topical
Antihypertensive Agents
Aqueous Humor
Brimonidine Tartrate
Clonidine
Fluorocarbons
Humans
Intraocular Pressure
Ocular Hypertension
Prospective Studies
Quinoxalines
Sulfonamides
Sulfur Hexafluoride
Thiophenes
Timolol
Vitrectomy